|Paget's disease, or "osteitis deformans",
is a benign condition of bone that
results in the thinning of bone, followed by redeposition in an irregular
manner--something that appears on X-ray as a so-called "woven bone"
Bone affected by Paget's disease is much
less stable than normal bone, and the condition may develop to the point of deformity.
Bowed legs, for example, are quite common.
Fractures, too, are much more likely to develop, as
affected bones are much more brittle.
Paget's disease may occur in one or several areas. It typically develops
over the age of 40. The skull and long bones are particularly
There appears to be some evidence that a viral
infection of the cells that remove bone (osteoclasts) is to blame. Blood
tests that may suggest Paget's Disease are urinary hydroxyproline and alakaline
Paget's Disease is associated with neurological
effects, arthritis, and an increased rate of cardiac failure.
While benign, Paget's disease may develop into a
malignant tumour of bone, like osteosarcoma, chondrosarcoma, and fibrosarcoma. Click on the link to visit the webpage
malignant tumours of bone.