Paget's Disease of Bone

Paget's disease, or "osteitis deformans", is a benign condition of bone that results in  the thinning of bone, followed by redeposition in an irregular manner--something that appears on X-ray as a so-called "woven bone"  appearance.

Bone affected by Paget's disease is much less stable than normal bone, and the condition may develop to the point of deformity.   Bowed legs, for example, are quite common.  

 

Fractures, too, are much more likely to develop, as affected bones are much more brittle.  

Paget's disease may occur in one or several areas.  It typically develops over the age of 40.  The skull and long bones are particularly vulnerable.  

There appears to be some evidence that a viral infection of the cells that remove bone (osteoclasts) is to blame.  Blood tests that may suggest Paget's Disease are urinary hydroxyproline and alakaline phosphatase.   

 

Paget's Disease is associated with neurological effects, arthritis, and an increased rate of cardiac failure.  

While benign, Paget's disease may develop into a malignant tumour of bone, like osteosarcoma, chondrosarcoma, and fibrosarcoma.  Click on the link to visit the webpage concerning malignant tumours of bone

 

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